
Paula's Choice Resist Super Antioxidant Serum is a product with 25 ingredients. Contains: Vitamins - Tocopheryl Acetate; Antioxidant - Tetrahexyldecyl Ascorbate, Tocopherol, Ubiquinone, Thioctic Acid, Tocopheryl Acetate, Magnesium Ascorbyl Phosphate, Ferulic Acid, Superoxide Dismutase, Glutathione, Glycine Soja (Soybean) Seed Extract;
Organic score: 24% natural, 52% chemical. Vegan - No; Cruelty free - Yes; Reef safe - Yes;
Positive effects
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INCI - Full Breakdown
Cyclopentasiloxane is a fluid silicone. It’s non-greasy and doesn’t have any scent or color. It evaporates pretty fast which makes this ingredient essential when it comes to making products that have to dry quickly. It also gives a nice silky feeling when you apply the product to the skin and hair. It leaves a thin film that protects the skin after evaporation.
Cyclopentasiloxane is chemically neutral, meaning it doesn’t react with other components.
Dimethicone is the most popular silicone. It makes the skin softer and forms a film adding smooth and silky feeling. This film not only improves how the skin feels but also works as a protective barrier. It also improves the visual appearance of your skin by filling small wrinkles. That's why some people think dimethicone removes wrinkles. Actually, it does not. It's just a visual effect.
One of the most important characteristics of this component is that it helps to spread other ingredients evenly on the surface to provide good coverage. It's very important because you want all your skin cells to receive an equal proportion of the components.
Dimethicone is considered as safe, but remember that it is rather difficult to wash off! This may lead to clogged pores and acne if you use it too often and don't wash off quite well.
Ceramide NP is one of the most important ceramides found naturally in human skin. It plays a key role in maintaining a strong, healthy moisture barrier — the skin’s protective shield. When this barrier is damaged, skin becomes dry, irritated, and more sensitive. It helps restore that balance.
In skincare formulas, the component works by filling in the microscopic gaps between skin cells, much like mortar between bricks. This strengthens the outer layer of the skin, reduces moisture loss, and enhances overall resilience. Products containing Ceramide NP are especially beneficial for dry, sensitive, or compromised skin, including conditions like irritation from over-exfoliating or cold weather exposure.
Its biggest advantage is biocompatibility: Ceramide NP closely mimics the skin’s own natural ceramides, making it highly effective and well-tolerated. When combined with cholesterol and fatty acids, its performance is even better, helping to rebuild the lipid barrier more efficiently.
Overall, Ceramide NP is a gentle yet powerful ingredient that supports long-term skin health by reinforcing hydration, smoothing texture, and improving the skin’s ability to protect itself.

Tocopherol is one of the most popular active ingredients in cosmetics. It’s a brilliant component. It's a form of Vitamin E and it does help the skin and hair a lot. It conditions the skin, strengthens its barrier, protects it against harm, and makes the tone even. It also helps your skin and hair to resist the sun. It’s safe but can irritate sensitive skin sometimes. Pay attention to concentration!
Tocopheryl Acetate is a form of Vitamine E. It’s used as an alternative to Tocopherol because it is more stable in the formulation. It has all the positive effects of Tocopherol plus better stability. It’s a brilliant component. It conditions and nourishes the skin helping it to resist aging. It also helps to protect the skin from the sun. High concentrations of Tocopheryl Acetate can lead to irritation and allergic reactions.
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